rejuran treatment korea
Rejuran treatment in Korea: what it is and how clinics plan it
Rejuran is a polynucleotide injection developed in Korea. This guide covers what its approval covers, how clinics plan sessions, what recovery looks like and who should avoid it.
What is Rejuran Treatment and How Does It Work?
What Clinics Use Rejuran For
Understanding the Collagen Regeneration Method
Who is an Ideal Candidate for Rejuran Treatment?
What to Expect During and After the Procedure
Comparing Rejuran Treatment with Other Skin Rejuvenation Therapies
How does Rejuran treatment enhance skin health?
Rejuran is a Korean injectable made from salmon-derived polynucleotides (PN). It is approved in Korea as a medical device, and the approved indication for Rejuran HB Plus is crow’s-feet wrinkles. Clinics also use it for texture and fine lines. Effects are gradual and vary between people, and it is not suitable for anyone with a fish allergy or during pregnancy.
What is Rejuran Treatment and How Does It Work?
Rejuran is made by the Korean company PharmaResearch from polynucleotides, purified DNA fragments taken from salmon. It is injected into the skin in many small doses. Unlike a hyaluronic acid filler, it is not meant to add volume.
The proposed mechanism is that polynucleotides support the skin’s repair processes, including fibroblast activity and collagen production. That rationale comes mostly from laboratory work and small clinical studies. Clinics describe gradual improvement in fine lines and texture, and how much change a person sees varies.
In Korea it is regulated as a medical device, and the approved indication for Rejuran HB Plus, which adds hyaluronic acid and lidocaine, is improving crow’s-feet wrinkles in adults. Clinics commonly use it on other parts of the face, which goes beyond that indication. Changes, if any, are usually described several weeks after treatment rather than after the first session. People comparing options often also read about InMode treatment in Korea, which works by heat rather than injection.
What Clinics Use Rejuran For
Clinics mainly offer Rejuran for fine lines, rough texture and skin that looks dull or thin. When people notice a change, it is usually from about four to six weeks after treatment, and results vary from person to person.
The injecting itself is fairly quick; allow extra time for numbing cream to work. Korean clinic pages we reviewed on 26 September 2026 commonly describe a first course of three to four sessions, two to four weeks apart. That is provider information rather than a trial-based standard, and how long any effect lasts has not been well measured.
Downtime is usually short. Redness and small bumps at the injection points tend to settle within a day or two, and a bruise, when one appears, can take up to about a week to clear. Plan events and photos with that in mind. The site also has a separate guide to the Cinderella drip, an IV infusion some visitors ask about; it is a different product with its own evidence and risks.
Understanding the Collagen Regeneration Method
Collagen is the main structural protein of the dermis, and it declines with age and sun exposure. Polynucleotides are thought to encourage fibroblasts, the cells that make collagen, to be more active. That is the rationale clinics give for Rejuran.
The clinical evidence is limited. Reviews of polynucleotide studies report improvements in wrinkle scores and skin measurements, but most studies are small, use different products and schedules, and follow people for a few months at most.
Because it relies on the skin’s own response, any change is gradual. Rejuran does not fill deep folds or replace lost volume. Clinics sometimes pair it with energy-based devices such as lifting lasers; ask the doctor how the two should be spaced.
Who is an Ideal Candidate for Rejuran Treatment?
Clinics usually offer Rejuran to adults with early signs of ageing, such as fine lines, dullness and mild laxity, who want a gradual change. It is not a filler and does not add volume.
People with deep wrinkles or marked sagging generally need a different treatment. Rejuran should be avoided or postponed if you have a fish or salmon allergy, because the product is salmon-derived; during pregnancy or breastfeeding, where no safety data exist; and where there is an active skin infection, including a cold sore, in the treatment area. Tell the doctor if you take anticoagulant or antiplatelet medicines, have a bleeding disorder, or have an autoimmune condition.
A consultation should cover your medical history and medicines, what you want to change, and whether another treatment would suit that concern better.
What to Expect During and After the Procedure
Rejuran treatment steps
- Preparation: The skin is cleansed thoroughly before treatment to minimize infection risk.
- Injection Process: Many small injections place polynucleotides into the dermis with fine needles, usually after numbing cream.
- Sensation: Patients may feel mild discomfort or a slight stinging during injections, which usually subsides quickly.
- Immediate Aftercare: Redness, small bumps and pinpoint bruising are common. Bumps and redness usually settle within a day or two; a bruise can take up to about a week to fade.
- Recovery: Most people return to ordinary activities the same day, although visible marks may last longer.
- Results Timeline: Any change in texture is usually described from about four to six weeks and varies between people.
- Maintenance: The first course is commonly three to four sessions two to four weeks apart. Clinics may suggest occasional sessions months later; there is no evidence-based maintenance interval.
Avoid strong sun and harsh skincare products for a few days while the skin settles. Sunscreen and a plain moisturiser are enough for most people.
Typical Rejuran course at Korean clinics
Comparing Rejuran Treatment with Other Skin Rejuvenation Therapies
- Mechanism of Action: Rejuran uses polynucleotides to stimulate natural collagen regeneration, whereas treatments like hyaluronic acid fillers provide immediate volume by adding substance beneath the skin. Laser therapies, in contrast, use controlled damage to trigger collagen production.
- Treatment Time: The injecting itself is short, but numbing cream adds time. Some laser procedures take longer.
- Recovery Time: Redness from Rejuran usually settles within a day or two, but a bruise can last about a week. Ablative lasers often need several days of recovery. Fillers also have short downtime but carry different risks, including rare blockage of a blood vessel.
- Collagen Effects: Rejuran is intended to support the skin’s own collagen production, which is why changes are gradual. Lasers also stimulate collagen through controlled heat or injury. Hyaluronic acid fillers mainly add volume.
- Suitability: Rejuran is used on many skin types, but people with a fish allergy, pregnancy or active skin infection should not have it. Some lasers carry a higher risk of pigment change in darker skin. Fillers can also cause allergic reactions in some people.
Which approach suits you depends on the concern, how much downtime you can accept and your medical history. None of these options is right for everyone, and direct comparisons between them are limited.
Frequently Asked Questions
Q : How long does it take to see results from Rejuran treatment?
a : Any change in texture or fine lines is usually described from about four to six weeks after treatment. Clinics generally judge the result after a course of sessions rather than after the first one.
Q : Are there any side effects or risks associated with Rejuran therapy?
a : Common effects are redness, swelling, small bumps and pinpoint bruising at the injection sites. Bumps and redness usually settle within a day or two; bruising can last up to about a week. Because Rejuran is made from salmon DNA, people with a fish allergy should not have it, and it is generally avoided in pregnancy, breastfeeding and active skin infection.
Q : How often do clinics repeat Rejuran?
a : Korean clinics commonly suggest three to four sessions, two to four weeks apart, as a first course. Any later maintenance interval is set by the clinic, often months apart, and no particular interval is backed by strong evidence.
Q : Can Rejuran treatment be combined with other skin care procedures?
a : Clinics often combine it with lasers or peels. The timing and spacing are the doctor’s decision, and fitting several procedures into one short trip increases the chance of overlapping redness or bruising. For pigmentation-focused treatment, see our guide to Rejuran Recovery Time: Planning It Around a Trip to Korea.
Q : Is Rejuran treatment suitable for all skin types and ages?
a : It is used on many skin types. Medical history matters more than skin type: fish allergy, pregnancy, breastfeeding, active infection and bleeding problems are the main points to raise with the doctor. It is not designed for deep wrinkles or major volume loss.
Summary
Overview of Rejuran Treatment as a Collagen Regeneration Therapy
Rejuran is a Korean injectable made from salmon-derived polynucleotides. In Korea it is approved as a medical device for crow’s-feet wrinkles, and clinics also use it for texture and fine lines. Changes are gradual and vary between people. It is not a filler, and it is not suitable for people with a fish allergy or during pregnancy.
Polynucleotides are thought to support fibroblast activity and collagen production; most of the evidence comes from small studies.
Korean clinics commonly describe three to four sessions, two to four weeks apart, as a first course.
Redness and bumps usually settle within a day or two; bruising can take up to about a week.
Any change usually shows from about four to six weeks; how long it lasts has not been well measured.
Avoid it with a fish allergy, during pregnancy or breastfeeding, or with an active skin infection, and mention blood thinners and autoimmune conditions.
IV drips are a separate topic; see our page on Rejuran Pain Level: What the Injections Actually Feel Like.
- Fat-Dissolving Injections in Korea
- InMode FX Before and After
- Skin Booster Side Effects: What to Expect
- InMode Results Timeline
- Skin Boosters in Korea
Sources & Verification Notes
We checked the approval status, evidence and prices on this page against the sources listed here on 26 September 2026.
- Rejuran HB Plus is a medical device in Korea with an approved indication of crow’s-feet wrinkles in adults; it contains polynucleotides, hyaluronic acid and lidocaine. (Dailypharm, 30 July 2021)
- The Cureus systematic review by Alhussain et al. (2026) reports that polynucleotide studies are small and varied and that reported reactions were mostly mild and local. (PMC13453133)
- The session plan (three to four sessions, two to four weeks apart) is taken from Korean clinic pages and is labelled as provider information.
- Prices: Goodoc’s Rejuran Healer page, showing promotional listing prices, was viewed on 26 September 2026: average 165,575 KRW, range 94,272 to 320,708 KRW per session, sample period not stated. (goodoc.co.kr)
Find a Clinic in Korea
For clinic lists by neighbourhood, compiled from Naver Place search results, see the Seoul Dermatology Clinics Directory and the Busan Dermatology Clinics Directory. They are directories, not rankings or recommendations; our Editorial & Evidence Policy explains how they are compiled.
This guide is written for readers who are visiting or considering visiting Korea for dermatology treatment. It’s general information, not medical advice or a personal recommendation. See our Medical Disclaimer before making a treatment decision, and confirm specific details, current pricing, and suitability directly with a clinic.
Note: We describe typical practice, not a guarantee. A dermatologist who examines you may recommend something different, and that advice should come first.
Research reference: The Effectiveness of Polynucleotides in Esthetic Medicine: A Systematic Review (PubMed).