rejuran before after
Rejuran before and after: what tends to change, and when
Rejuran is an injectable polynucleotide product. The changes it brings are gradual and usually modest, so it helps to know what to look for in before and after photos and what the evidence does not show.
Understanding Rejuran: What It Is and How It Works
Rejuran Before and After: What Changes Show Up
Timeline of Skin Improvement After Rejuran Treatment
What Rejuran Is Used For, and Its Limits
Factors Influencing Rejuran Treatment Outcomes
Aftercare and Who Should Not Have Rejuran
What skin improvements occur after Rejuran treatment and when?
Rejuran is a polynucleotide (PN) injection made from purified salmon DNA fragments. In Korea it is approved as a medical device, and the approved indication for Rejuran HB Plus is crow’s-feet wrinkles. The changes people describe, such as smoother texture, build slowly over several weeks, vary from person to person and are not dramatic volume changes.
Understanding Rejuran: What It Is and How It Works
Rejuran is an injectable made from polynucleotides, which are purified DNA fragments taken from salmon. It is not a volume filler. The proposed mechanism is that polynucleotides support the skin’s own repair activity, including the fibroblasts that make collagen; much of that evidence comes from laboratory work and small clinical studies rather than large trials.
The product is placed in the dermis with many small injections. Because it does not add volume, any change appears over weeks rather than on the day, so a before photo and an after photo taken in the same week tell you very little. For practical details on having it done in Korea, see our Rejuran treatment in Korea guide.
Clinics mainly offer it for fine lines, rough texture and dull-looking skin. The approved indication in Korea is narrower (crow’s-feet wrinkles), so treating other areas or concerns is the clinic’s choice rather than part of the approval.
Rejuran Before and After: What Changes Show Up
Before and after photos of Rejuran usually show small differences in texture and fine lines. When you look at clinic photos, check whether the lighting, camera angle, makeup and expression match, and whether the clinic says how many sessions were done and how long after the last one the photo was taken. Photos chosen by a clinic show its best cases, not the typical one.
When people notice a change, they usually describe it from around four to six weeks after treatment. Korean clinic pages we reviewed on 26 September 2026 commonly describe a first course of three to four sessions, two to four weeks apart. That is provider information: published studies use a range of different schedules.
What the studies measure is modest. A 2026 systematic review of polynucleotide studies describes the evidence as limited by small samples, differing protocols and varied outcome measures. We found no reliable evidence that Rejuran results last longer than those of other skin treatments, and head-to-head studies are few. For a different before-and-after topic, see InMode FX before and after.
Timeline of Skin Improvement After Rejuran Treatment
In the first days, the visible signs come from the injections themselves: small bumps that usually settle within a few days, redness, and sometimes bruising, which can take up to about a week to fade. Any change in texture is usually described from several weeks after the session.
Because polynucleotides are not a filler, there is no instant change in shape. That is the main practical difference from hyaluronic acid fillers, which change contour on the day.
Clinics usually plan a short course and judge the outcome a few months after the last session. Nobody can promise a particular result or the date it will appear. If you want to know what the injections feel like, see our note on Rejuran pain level.
What Rejuran Is Used For, and Its Limits
Clinics offer Rejuran for fine lines, rough texture, enlarged-looking pores and dull skin. Small studies report improvements in wrinkle scores and skin measurements, but the studies are small and their methods differ.
The injections are minimally invasive and most people go back to ordinary activities the same day. Visible marks can outlast that day, and a bruise, if one appears, can take up to about a week to clear, which matters if you have an event or a flight soon after.
The main trade-off is time. Changes build gradually and are modest, so Rejuran does not suit someone who wants a visible change for a date a few days away. It does not replace lost volume or treat deep folds.
Factors Influencing Rejuran Treatment Outcomes
What shapes your results
Skin condition at baseline
The starting condition of the skin affects how much change is visible.
Number of sessions
Clinics commonly plan three to four sessions, two to four weeks apart, and assess the result after the course rather than after one session.
Treatment technique
Injection depth, dosage, and practitioner skill affect how well the polynucleotides stimulate skin repair.
Lifestyle factors
Sun exposure, smoking, and skincare habits can either support or hinder skin regeneration post-treatment.
Individual biological response
Age and individual healing differ, so two people given the same course can see different results.
None of these can be predicted precisely, so treat any clinic estimate of your result as a rough guide.
Aftercare and Who Should Not Have Rejuran
- Know the plan before you start: If the clinic proposes a course, ask how many sessions, how far apart, and the total price before the first one.
- Protect skin from UV exposure: Use broad-spectrum sunscreen daily, especially while the injection marks heal.
- Follow a gentle skincare routine: Avoid harsh exfoliants or irritating products that may disrupt the healing process and reduce treatment benefits.
- Keep the skin moisturised: A plain moisturiser is enough while the injection marks settle.
- Ask before combining treatments: If you plan lasers or other injections on the same trip, ask the doctor how far apart to space them.
Who should not have Rejuran, or should ask first: anyone allergic to fish or salmon, because the product is salmon-derived; people who are pregnant or breastfeeding, since there is no safety data for them; anyone with an active skin infection or cold sore in the area; and people taking blood thinners or with a bleeding tendency, who bruise more easily. Also tell the doctor about autoimmune conditions and any history of keloid scars.
Frequently Asked Questions
Q : Is Rejuran treatment suitable for all skin types?
a : Most skin types can be treated, but suitability depends on health history more than skin type. Because Rejuran is made from salmon DNA, tell the clinic about any fish allergy. It is generally avoided during pregnancy and breastfeeding and over an active infection, and needs extra care if you take blood thinners. A doctor should confirm it suits you.
Q : How many Rejuran sessions do clinics usually suggest?
a : Korean clinic pages commonly describe three to four sessions spaced two to four weeks apart. That is a clinic protocol rather than a fixed rule, and the doctor may suggest fewer or more.
Q : Are there any side effects or downtime after Rejuran treatment?
a : Expect small bumps and redness at the injection points, which usually settle within a few days. Bruising is less predictable and can last up to about a week, particularly around the eyes. Most people return to normal activities the same day, but plan photos and events around the possible bruising.
Q : Can Rejuran be combined with other skin treatments?
a : Clinics often combine it with other treatments. Whether that suits you, and how far apart to space them, is a decision for the treating doctor.
Q : What is the typical cost range for Rejuran treatments?
a : When we checked on 26 September 2026, Goodoc, a Korean clinic-booking platform, listed an average promotional price of 165,575 KRW per Rejuran Healer session, with listings from 94,272 to 320,708 KRW. The page does not say which period or how many clinics these figures cover, and a course means several sessions. For a related treatment, see Rejuran Treatment in Korea: Approval, Sessions, Risks and Prices.
Summary
Overview of Rejuran: Mechanism, Results, and Timeline
Rejuran is an injectable made from salmon-derived polynucleotides. In Korea it is approved as a medical device for crow’s-feet wrinkles, and clinics also use it for texture and fine lines. Any change is gradual and modest, builds over weeks and differs between people. It is not for everyone: fish allergy, pregnancy and active skin infection are reasons to avoid or postpone it.
Rejuran is placed in the dermis with many small injections and does not add volume. For practical details on having it in Korea, see our Rejuran treatment guide.
Changes people describe, such as smoother texture, usually become noticeable from about four to six weeks after treatment, if at all.
Korean clinics commonly propose three to four sessions, two to four weeks apart; this is a clinic protocol rather than a fixed standard.
Factors influencing results include the patient’s initial skin health, treatment technique, adherence to session schedules, and lifestyle choices like sun protection and skincare routines.
Redness and small bumps usually settle within days; bruising can last up to about a week. Keep expectations modest and avoid harsh skincare products while the skin heals.
- Skin Boosters in Korea
- Laser Toning Side Effects
- Rejuran Recovery Time
- Fat-Dissolving Injections in Korea
- Contour Injection Side Effects
Sources & Verification Notes
The facts and figures on this page were checked against the sources below on 26 September 2026.
- Approval in Korea: Rejuran HB Plus is approved as a medical device, and its indication is improving crow’s-feet wrinkles in adults. That is narrower than the texture and fine-line uses clinics offer. (Dailypharm, 30 July 2021)
- Evidence: a 2026 systematic review in Cureus (Alhussain et al.) found that polynucleotide studies are small, use different products and schedules, and mostly report mild, short-lived local reactions. It sets no standard number of sessions. (PMC13453133)
- Session schedule: “three to four sessions, two to four weeks apart” is how Korean clinic pages described their protocol when we checked; it is provider information, not a trial result.
- Price: Goodoc promotional listing prices for Rejuran Healer, viewed 26 September 2026 (goodoc.co.kr). The page does not state its sample or period.
- Who should avoid it: the fish-allergy, pregnancy and infection cautions reflect the salmon origin of the product and standard injection precautions. We could not read the full Korean product insert, so ask the clinic to show you its warnings.
This guide is written for readers who are visiting or considering visiting Korea for dermatology treatment. It’s general information, not medical advice or a personal recommendation. See our Medical Disclaimer before making a treatment decision, and confirm specific details, current pricing, and suitability directly with a clinic.
Note: Where studies are cited, we summarise them in plain language; the original papers describe their own limitations in more detail.
Read the underlying study: The Effectiveness of Polynucleotides in Esthetic Medicine: A Systematic Review (PubMed).